Rheumatoid arthritis is a condition characterized by inflammation of the peripheral joints of the hands, wrists, elbows, shoulders, hips and feet. The disease affects both the body side and leads to the destruction of the joints.
The process is characterized by persistent inflammation of the synovial membrane of joints, cartilage surface, which leads to deformation and bone erosion. Usually it affects only the joints, but there are cases of spread of inflammation in the lungs, heart and nervous system.
Celebrex is considered to be one of the best among the newest non-steroidal anti-inflammatory drugs possessing a high degree of intensity with respect to relief of pain. It belongs to the pharmacological group of agents that possess selective activity against stimulation of COX. These biological substances reduce the susceptibility of prostaglandins of antibodies and content of mast cells.
Due to this, the use of Celebrex reduces body temperature in inflammatory processes, including congestion, edema and local hyperthermia in affected large joints and spine.
The drug can be used as the main therapeutic agent in all cases when you want to eliminate the influence of the inflammatory component. There occurs pain eliminating effect due to blocking of swelling.
Celebrex is available in capsule form. There is the active ingredient Celecoxib inside gelatin shells that dissolve in the small intestine. Capsules can be of 100 mg and 200 mg. Dosage is determined by the attending physician according to the patient’s general condition, its weight, age and severity of damaged tissue.
Non-steroidal anti-inflammatory effect of the drug is based on its ability to antagonize the production of inflammatory agents.
The assimilation of the active substance is derived in the small intestine. The maximum concentration in the blood is achieved within 40 – 50 minutes after intake.
You should know that the use of Celebrex capsules or tablets on a background of oily and junk food greatly reduces the effectiveness of the drug. Therefore, you should take the medication on an empty stomach or within 1.5 hours after a meal.
There is specific guidance with respect to certain groups of patients given in the instruction.
First of all, it is worth considering:uncontrolled increase in the concentration of the active substance in the blood of patients who are older than 60 years;representatives of the Asian peoples suffer from unpredictable allergic reactions to the use of capsules, so the treatment begins with a minimal dose of trial;persons with a body weight less than 50 kg are recommended to take 200 mg daily;patients suffering from liver, gall bladder and kidneys failure should be under doctors’ supervision; moreover, there is needed regular biochemical analysis of blood.
The main indication for the use of Celebrex is a comprehensive treatment of inflammatory and destructive diseases of the musculoskeletal system.
This may be the following condition:
- rheumatoid arthritis;
- osteochondrosis of the spine;
- not incarcerated hernia of the vertebral disc in the stage of sciatica;
- deforming osteoarthritis;
- arthritis of various etiologies.
Moreover, Celebrex is used to eliminate pain syndromes associated with lesions of the muscle tissue by lactic acid. It can be a pain in the back and limbs after exercise. The remedy also helps to eliminate post-operative pain after injury. It is highly effective for complex therapy of herpes zoster, intercostal neuralgia, inflammation of the trigeminal nerve.
Women successfully use the drug for painful menstruation. Celebrex can be used by pregnant women only under specialist’s supervision.